Neurotherapeutics and Clinical Pharmacokinetics Laboratory (Neuro-CPK)
Welcome to the Neurotherapeutics and Clinical Pharmacokinetics Laboratory!
The overall goal of the Neuro-CPK lab is to translate benchside and bedside observations into clinical practice protocols that will potentially improve outcomes in patients with neurological illnesses including neurocritical care population. This is being achieved through a myriad of research methodologies such as pharmacokinetic studies, pharmacokinetic-pharmacodynamic modeling, development and validation of analytical techniques, inflammation research, critical appraisal of clinical trials, systematic reviews and meta-analyses, design and conduct of retrospective and prospective observational studies and clinical trials.
In addition, we collaborate in clinical pharmacokinetics and pharmacogenomics research projects spanning other disease conditions
Hayashi M, Hamdy DA, Mahmoud SH. Applications for pharmacogenomics in pharmacy practice: A scoping review. Research in Social and Administrative Pharmacy (Aug 2021)
Background: Pharmacogenomics (PGx) can provide valuable pharmacokinetic and pharmacodynamic information for the pharmacist's assessment of drug therapy, especially within medication therapy management (MTM) services. However, no review has comprehensively mapped the pharmacists' use of PGx in practice-based research. Doing so would allow future researchers, practitioners, and policy-makers to identify the ideal populations and settings for PGx implementation within the pharmacy.
Objective: The purpose of this review is to identify the evidence to date of PGx use in pharmacy practice.
Methods: A scoping review was conducted to find all studied non-oncologic pharmacy practices incorporating PGx testing. Search terms were applied to 5 databases and relevant journals. Characteristics of patients, pharmacy settings, genetic tests, and outcomes were summarized to determine models most likely to benefit patients.
Results: The search identified 43 studies on the use of PGx by pharmacists published between 2007 and 2020. CYP2C19 testing with antiplatelets was the most studied model, found in both community and institutional settings. It also was the most actionable test: approximately 30% of patients have polymorphisms indicating a need for alternative antiplatelets, and identifying these patients can reduce morbidity and mortality by more than 50%. As technology shifts, broader studies using multi-gene panel tests within MTM demonstrate an approximate 50% decrease in emergency visits and hospitalizations in elderly polypharmacy patients. Clinical benefit or drug-gene interactions are also found in other cardiovascular, psychiatric, analgesic, and gastrointestinal indications. No evaluations of actual costs or of pharmacist prescribing within pharmacy-based PGx have been performed. Facilitators towards successful PGx implementation included pharmacist education, collaboration with other healthcare providers, and the use of clinical decision software.
Conclusions: Pharmacogenomic testing has demonstrated feasibility and improved medication outcomes in pharmacy practice, including in the community pharmacy. Further PGx research should be directed towards pharmacist prescribing, pharmacist education, and pharmacoeconomics.