Neurotherapeutics and Clinical Pharmacokinetics Laboratory (Neuro-CPK)

The Neurotherapeutics and Clinical Pharmacokinetics (Neuro-CPK) Laboratory, led by Dr. Sherif Mahmoud, specializes in advancing treatments for neurological disorders, with a focus on neurocritical care and epilepsy. Dr. Mahmoud's research centers on understanding how neurological injuries influence drug action and disposition. The lab bridges basic research with clinical applications to improve patient outcomes. The overall goal of the Neuro-CPK lab is to translate benchside and bedside observations into clinical practice protocols that will potentially improve outcomes in patients with neurological illnesses including neurocritical care population. This goal is pursued through diverse methodologies, including critical appraisal of clinical trials, systematic reviews and meta-analyses, design and conduct of retrospective and prospective observational studies, pharmacokinetic studies and clinical trials. Additionally, the lab incorporates wet lab techniques to investigate the underlying pathophysiological changes driving observed alterations in drug pharmacokinetics and pharmacodynamics. This multifaceted approach enables a comprehensive understanding of the challenges faced by patients with neurological conditions, guiding tailored therapeutic strategies to improve efficacy and safety.

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In addition, we collaborate in clinical pharmacokinetics and pharmacogenomics research projects spanning other disease conditions